Health Care Providers (HCPs)


Anticoagulant Prescription Details

Single-Drug Therapy Options

Apixaban Rivaroxaban
Apixaban 5 mg tablets

Sig: two tablets BID for 7 days, then one tablet (5 mg) PO BID thereafter

Dispense 74 tablets for first 30 days

Dispense 60 tablets each subsequent month (at least 2 more months)

Rivaroxaban “Starter Pack”

Sig: Take as directed by starter pack

Starter pack provides a 30 day supply:

  • 15 mg PO BID with food (42 tablets) for the first 21 days
  • 20 mg PO daily with food (9 tablets) for days 22-30

Dispense 30 tablets of 20 mg each subsequent month (at least 2 more months)

Avoid use if CrCl < 30 mL/min

If starter pack is unavailable:

Write for Rivaroxaban as indicated above 

Prescription Assistance
Apixaban ( and

  • Non-Medicare Part D patients with low income
  • Copay Card for non-government insurance
  • 30-day trial for all patients


Rivaroxaban (

  • Co-pay assistance (for non-Medicare/non-Medicaid)
  • 30-day trial card for all patients
  • Johnson & Johnson Patient Assistance Foundation
  • State-sponsored Programs
  • Medicare Part D Low-Income Subsidy


Two-Drug (LMWH Bridging) Therapy Options



Warfarin Dabigatran Edoxaban
LMWH 1.5 mg/kg dosing subcutaneously daily (or 1 mg/kg Q12H daily)

  1. Starter therapy for ALL two-drug options
  2. LMWH 1 mg/kg dosing subcutaneously daily if CrCl<30 mL/min
  3. Do not use LMWH if patient is on hemodialysis
Warfarin 5mg daily – start on day 1

  1. Do not use if pregnant
  2. Supply enough for at least 3 months
Dabigatran 150mg tablet twice daily starting after 5-10 days of LMWH

  1. Dispense 60 tablet per month (at least 3 months)
  2. Do not use if Cockcroft-Gault CrCl<30 mL/min
  3. Fondaparinux can be used in place of LMWH
Edoxaban 60mg tablet daily after 5-10 days of LMWH

  1. Dispense 30 tablets per month (at least 3 months)
  2. Reduce edoxaban dose to 30mg daily if Cockcroft-Gault CrCl 15-50 mL/min or weight ≤60 kg or use of strong P-gp inhibitor
  3. Fondaparinux can be use in place of LMWH


Dabigatran (

  • Commercial insurance may save up to $2400 over one year
  • 30-day trial for all patients
Edoxaban (

  • $4 for 30 days, or $12 for 90 days of medication
  • Not valid for Medicare Part D and Medicaid patients

References: FDA prescribing information (