DEEP VEIN THROMBOSIS

Single-Drug Therapy Options

Sig: two tablets BID for 7 days, then one tablet (5 mg) PO BID thereafter

Dispense 74 tablets for first 30 days

Dispense 60 tablets each subsequent month (at least 2 more months)

Sig: Take as directed by starter pack

Starter pack provides a 30 day supply:

• 15 mg PO BID with food (42 tablets) for the first 21 days
• 20 mg PO daily with food (9 tablets) for days 22-30

Dispense 30 tablets of 20 mg each subsequent month (at least 2 more months)

Avoid use if CrCl < 30 mL/min

Write for Rivaroxaban as indicated above 

• Non-Medicare Part D patients with low income
• Copay Card for non-government insurance
• 30-day trial for all patients

• Co-pay assistance (for non-Medicare/non-Medicaid)
• 30-day trial card for all patients
• Johnson & Johnson Patient Assistance Foundation
• State-sponsored Programs
• Medicare Part D Low-Income Subsidy

Two-Drug (LMWH Bridging) Therapy Options

1. Starter therapy for ALL two-drug options
2. LMWH 1 mg/kg dosing subcutaneously daily if CrCl<30 mL/min
3. Do not use LMWH if patient is on hemodialysis

1. Do not use if pregnant
2. Supply enough for at least 3 months

1. Dispense 60 tablet per month (at least 3 months)
2. Do not use if Cockcroft-Gault CrCl<30 mL/min
3. Fondaparinux can be used in place of LMWH

1. Dispense 30 tablets per month (at least 3 months)
2. Reduce edoxaban dose to 30mg daily if Cockcroft-Gault CrCl 15-50 mL/min or weight ≤60 kg or use of strong P-gp inhibitor
3. Fondaparinux can be use in place of LMWH

• Commercial insurance may save up to $2400 over one year
• 30-day trial for all patients

• $4 for 30 days, or $12 for 90 days of medication
• Not valid for Medicare Part D and Medicaid patients