Guideline Recommendation for DOAC as first line therapy:
Use of a direct oral anticoagulant (apixaban, dabigatran, edoxaban, or rivaroxaban) is considered first line therapy for treatment of acute deep vein thrombosis and is recommended preferentially over warfarin therapy. (American College of Chest Physicians Guideline, 2016).
Reference: Chest 2016;149:315-52